[Immunotherapy]
 

Cancer Research

Of our many medical camps dedicated to the cancer battle, research is the ultimate bastion of hope. For the physician on the front line of patient care, research offers the real possibility that he or she will have more powerful and effective weapons to use in preventing, diagnosing and treating cancer. For the cancer victim, participating in a research clinical trial is sometimes the only remaining recourse to stopping an opponent that otherwise won't be stopped.

Medical research is also a lively and long-standing enterprise here. The medical center has 39 principal investigators on its staff, pursuing a wide range of research activities, including some 162 human studies and clinical trials. Pending grants total nearly $20 million -- a 115 percent increase over last year. As the newest major research initiative, the medical center has opened the Center for Stem Cell Biology, the only program of its kind in the state.

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Since 1998, when human pluripotent stem cells were first isolated, research on stem cells has received much public attention, both because of its extraordinary promise and because of relevant legal and ethical issues. Underlying this recent public scrutiny is decades of painstaking work by scientists in many fields, who have been deciphering some of the most fundamental questions about life with the goal of improving health.

In the last several decades, investments in basic research have yielded extensive knowledge about the many and complex processes involved in the development of an organism, including the control of cellular development. But many questions remain. How does a single cell - the fertilized egg - give rise to a complex, multi-cellular organism? The question represents a fundamental challenge in developmental biology. Researchers are now seeking to understand in greater detail the genetic factors that regulate cell differentiation in early development.
Source: National Institutes of Health