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Immunotherapy

IMMUNOTHERAPY PROTOCOLS

MM-001: A Phase 1 Study of Anti-CD38 CAR-T Therapy in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)
Principle Investigator: Todd Roberts, MD

Eligibility Criteria:

Population 1:
Adults with RRMM after receiving at least the following:

  • Lenalidomide (Revlimid®)
  • Pomalidomide (Pomalyst®)
  • Bortezomib (Velcade®)
  • Carfilzomib (Kyprolis®)
  • Daratumumab (Darzalex®)

Or

Population 2: 
Adults with RRMM within 1 year of receiving Autologous Stem Cell Transplant and:

  • Measurable Disease 
  • No myeloma involvement of the central nervous system, 
  • brain metastasis, or spinal cord compression
  • No active plasma cell leukemia
  • Good performance status

Contact Information:
Alexandra Milhaupt BSN, RN
Immunotherapy Nurse Coordinator
Office of Therapeutic Development
Phone: (401) 456-2526
alexandra.milhaupt@CharterCARE.org

 

CEA-001: A Phase 1 Study of Anti-CEA CAR-T Therapy for Patients with Pancreatic Cancer Liver Metastases
Principle Investigator: Steven Katz, MD, FACS

Eligibility Criteria:

  • Tumor must be CEA-expressing (CEA >10)
  • Liver metastases must be documented
  • Failed at least one line of standard chemotherapy
  • Good performance status

Contact Information:
Gabrielle Masse BSN, RN
Immunotherapy Clinical Research Nurse
Office of Therapeutic Development
Phone: 401-456-2659
gabrielle.masse@chartercare.org

 

RWMC-IPC 001 Peritoneal Carcinomatosis or Malignant Ascites (RWH 340-74)

Phase 1 Trial of Anti-CEA CAR-T Cell Intraperitoneal Infusions for Treatment in Patients with CEA+-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites. (RWH 340-74)

 

Contact Information

(All team members listed below are located at Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI 02908)

Ashley Moody, BSN, RN (Immunotherapy Research Nurse Manager)
401-456-2268                                                                                                                                    
Email: alarkin@chartercare.org                                                                      

Alexandra Milhaupt, BSN, RN (Immunotherapy Nurse)      
401-456-2526      
Email: alexandra.milhaupt@chartercare.org  

Catherine Conley, BS (Immunotherapy Research Data Collection Manager)
401-456-2397
Email: Catherine.conley@chartercare.org